Lavitra online - Medical Abstract April 14, 2005

PDE-5 inhibitor, Vardenafil, increases circulating progenitor cells in humans.

Foresta C, Lana A, Cabrelle A, Ferigo M, Caretta N, Garolla A, Palu G, Ferlin A.

1Department of Histology, Microbiology, and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy.

Bone marrow-derived endothelial progenitor cells (EPCs) originate from haematopoietic stem cells in bone marrow and migrate into the peripheral circulation to promote endothelial repair and neovascularization. The number of circulating progenitor cells is reduced in patients with cardiovascular risk factor. The aim of our study was to determine the number of these cells in healthy patients and to evaluate the effect of Vardenfil, a phosphodiesterases-5 (PDE-5) inhibitor, in the number of circulating EPCs. In our study, we found a significant increase in the number of these cells after the drug administration.International Journal of Impotence Research advance online publication, 14 April 2005;

Sourced at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15829988&query_hl=6

Lavitra Online